Reading entertain Cardiff City at the Madejski Stadium. Cardiff rescued a dramatic point on their last league visit here, scoring twice in the final 10 minutes to draw 2-2.
Sheffield United take on Crystal Palace at Bramall Lane in the Premier League. This is the Blades' first home game back in the top flight.
New Chelsea boss Frank Lampard takes charge of his first home game as his side welcome Brendan Rodgers' Leicester City. A Jamie Vardy strike saw the Foxes win 1-0 here last season.
Wolves take on Manchester United at Molineux in the first Monday Night Football of the new season. United were defeated on both of their visits here last season - in league and cup.
APOEL welcome a young and exciting Ajax side to Cyprus for the first leg of their UEFA Champions League play-off tie.
Fresh from knocking out Celtic, Cluj resume their UEFA Champions League journey as they host Slavia Prague in the play-offs.
Preston North End take on Stoke City at Deepdale in the Sky Bet Championship. A four-goal thriller ended level in a 2-2 draw last season.
Charlton Athletic take on Nottingham Forest in the Sky Bet Championship.
Young Boys host Red Star in the first leg of the UEFA Champions League play-offs. Belgrade look to improve their form on the road, having gone seven UEFA away games without a win.
Olympiacos and Krasnodar square-off in the first leg of the UEFA Champions League play-offs. The Greek side are yet to concede in four UEFA games this season.
Nenad Bjelica's Dinamo Zagreb side meet Rosenborg in the first leg of the UEFA Champions League play-offs. The visitors are facing Croatian opposition for the first time.